CHEN, Yiru

Undergraduate Student

Zhejiang University-University of Edinburgh Institute

Zhejiang University, China

Email: yiru.22@intl.zju.edu.cn

Hi there! My name is Yiru CHEN, and I am currently an undergraduate student in the Bioinformatics program at the Zhejiang University-University of Edinburgh (ZJE) Institute, Zhejiang University, China. I am pursuing a dual-award Bachelor of Science degree in Bioinformatics and am expected to graduate in 2026.

Research Interests

I am particularly interested in developing computational methods and modeling for biomedical data, including spatial multi-omics, computational immunology, and AI-driven approaches for biological data analysis. I believe critical biological insights are hiding in these complex data representations and are waiting to be discovered through innovative computational approaches.

Keywords: Spatial Multi-Omics, Computational Immunology, Computational Method Development, AI

Academic Background

I have received extensive computational biology academic training from multiple prestigious research institutions, including:

Zhejiang University (Current institution)
Vanderbilt University (Remote and on-site collaboration)
Georgia Institute of Technology (Remote collaboration)

With a strong foundation in programming, statistics, and machine learning, I am passionate about bridging the gap between computational innovation and biological discovery.

Current Research Focus

I am actively engaged in several research projects involving:

Spatial transcriptomics and metabolomics integration
T cell receptor repertoire analysis in spatial context
Statistical modeling and simulation of spatial transcriptomics data
Lineage-resolved single-cell mapping with spatial data

Feel free to explore my research projects, publications, and ongoing work through this website!

news

Jan 15, 2025	🏆 Best Poster Presentation Award at GPB Omics & Bioinformatics Frontiers Symposium for our SpatialTCR project!
Jan 10, 2025	SpatialMETA Paper Accepted
Dec 01, 2024	🚀 Excited to start a new independent research project on SpatialTCR - developing an integrated platform for spatial T cell receptor sequencing!ut: post date: 2016-01-15 07:59:00-0400 inline: true related_posts: false A simple inline announcement with Markdown emoji!

selected publications

Cell Discov

A pan-disease and population-level single-cell TCR repertoire reference

Ziwei Xue, Lize Wu, Bing Gao, and 12 more authors

Cell Discovery, 2025

Bib

@article{xue2025pancancer,
  title = {A pan-disease and population-level single-cell TCR repertoire reference},
  author = {Xue, Ziwei and Wu, Lize and Gao, Bing and Tian, Ruonan and Chen, Yiru and Qi, Yicheng and Dong, Tianze and Bai, Yadan and Zhao, Yu and He, Bing and Wang, Lie and Liu, Zuozhu and Yao, Jianhua and Lu, Linrong and Liu, Wanlu},
  journal = {Cell Discovery},
  year = {2025},
  status = {Accepted},
}

Nat Commun

Integrating Cross-Sample and Cross-Modal Data for Spatial Transcriptomics and Metabolomics with SpatialMETA

Ruonan Tian, Ziwei Xue, Yiru Chen, and 9 more authors

Nature Communications, 2025

Bib

@article{tian2025spatialmeta,
  title = {Integrating Cross-Sample and Cross-Modal Data for Spatial Transcriptomics and Metabolomics with SpatialMETA},
  author = {Tian, Ruonan and Xue, Ziwei and Chen, Yiru and Qi, Yicheng and Zhang, Jian and Yuan, Jie and Ruan, Dengfeng and Lin, Junxin and Liu, Jia and Wang, Di and Ye, Youqiong and Liu, Wanlu},
  journal = {Nature Communications},
  year = {2025},
  status = {Accepted},
}

GPB Symp

SpatialTCR: An integrated platform for high-resolution spatial sequencing of T cell receptor repertoires

Ruonan Tian, Yiru Chen, Yicheng Qi, and 3 more authors

In GPB Omics and Bioinformatics Frontiers Symposium, 2025

Co-first author, Presenting author

Bib

@inproceedings{chen2025spatialtcr,
  title = {SpatialTCR: An integrated platform for high-resolution spatial sequencing of T cell receptor repertoires},
  author = {Tian, Ruonan and Chen, Yiru and Qi, Yicheng and Xue, Ziwei and Yu, Zhejian and Liu, Wanlu},
  booktitle = {GPB Omics and Bioinformatics Frontiers Symposium},
  year = {2025},
  status = {Best Poster Award},
  note = {Co-first author, Presenting author}
}